Hi,

I am taking 1/2 a pill a day and have just recently started. My prescription is for 50 mg but I broke the pills in half to begin with. I've noticed a very slight decrease in consumption (3/4 a bottle of wine as opposed to the whole thing for example). Will the 50 mg cut this back even more? And, is the effect of this medication cumulative?

I've read a few places that the first couple doses should be 25mg, followed by 50 thereafter as a recommended dose. I don't think there is a definitive answer to what the effects will be upping your dose to 50 mg. Do you feel any side affects now? Some will up their dose to 75 or 100 if they have family history or suffer from cravings. One study found liver damage started to occur at 300 mg./day, so you should be fine going up to 50. Cumulative? Each time you drink with the correct dosage (usually 50 mg. to 100 mg.) of Naltrexone in your system, pharmacological extinction occurs. Pharmacological extinction is what makes you un-learn addiction.