"According to the late clinician John R Lee, M.D., estrogen dominance is behind many cases of midlife hypothyroidism, in which there are inadequate levels of thyroid hormone. When estrogen is not properly counterbalanced with progesterone, Dr. Lee surmised, it can block the action of thyroid hormone, so that even when the thyroid is producing normal levels of the hormone, the hormone is rendered ineffective and the symptoms of hypothyroidism appear.
In this case, laboratory tests may show normal thyroid hormone levels in a woman’s system, because the thyroid gland itself is not malfunctioning. This problem is compounded when a woman is prescribed supplemental estrogen, which then leads to an even greater imbalance. Prescribing supplemental thyroid hormone in that case will fail to correct the underlying problem: estrogen dominance."
And the missing link:
https://www.scientificamerican.com/article/shes-hooked/"In female mammals, estrogen does not act alone, however. Its hormonal partner, progesterone, appears to oppose estrogen’s ability to promote addictive tendencies."
And:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683955/This also aligns with Joanna's post:
"This is really important for lots of reasons. It can help you understand that things are good overall, but that perhaps just this week your brain is trying to fool you into any excuse to give up. It an also give you an insight into trends - especially for a woman, this is important because when you document it, some women can clearly see an upturn in drinking behaviour at certain times of the month. During those times, progesterone falls which in turn causes a weaker response to naltrexone."
This doesn't seem to be the situation in
every instance, but there seems to be a strong tendency towards estrogen dominance fueling addictive behavior. From what I understand, Dr. Northrup is also saying that estrogen dominance also binds certain thyroid hormones and makes them unavailable. Add to this that progesterone has a GABA-like effect on the brain (as does alcohol).
Aromatization of androgens to estrogen (by alcohol) would seem to add to the problems.