There has been some controversy over Nodict because of one post from a TSM member. To clarify, Nodict is not a time released tablet. It is a compressed tablet with a very thin coating. This coating makes it easier to swallow and improves the appearance of the tablet. It does not cause it to become a time released tablet. Time released tablets require a special matrix type of formulation, which would greatly increase the cost of the tablet. An analogy would be the red coated 500mg Tylenol tablets. They also are not long acting, however the red coating is attractive and some think easier to swallow. River has been a trusted source of naltrexone for many years and we continue to support the efforts and hard work of all the members of TSM. If anyone has questions, please contact Debbie at River. If anyone wants to order Naltima, please call our help line. We supply both Nodict and Naltima and both are good products - neither of which are time released.

NOTE: This thread was created by either an employee or owner of River Pharmacy, the primary distributor of Nodict. Please treat this information like you would any advertisement to buy something. The poster provided no credentials to back up his/her claims, or knowledge of TSM and/or Naltrexone.

Sun Pharmaceutical is the manufacturer of Nodict. Their information on google is a bit confusing. Here may lie the confusion taken from their company profile:
"1998: The company acquires brands from Natco Pharma, including time-release technology"

However, I have confirmed with Sun Pharma that Nodict is not a time released tablet.

Debbie at River


***Moderator Note: Merged from separate thread to avoid confusion***

“Debbie” at River has the qualification to PERHAPS be my gardener. Her position is MARKETING at River Pharmacy.

See a bit of a conflict???

Folks, let's not get excited too much. Debbie is 100% right - Nodict is not a time released formulation. In theory, the coating should have no effect. And maybe it does not - we really don't have a proof!

And Debbie has been utmost professional and helpful. Yes, she is in the business of reselling tablets but there are no signs whatsoever that she ever attempted to mislead anyone.

Going back to Nodict vs Naltima. I no longer believe it's the coating (or primarily it is). Several months of chewing the tablets did not do much. I am starting to think it's the amount of active substance (variation: inhibitory contaminant present) or OR our organisms really can get used to Nal and over time require higher doses to have the same effect (not an unusual thing with many drugs). Two Nodict tablets seem to do the job for me now. My Naltima will hopefully arrive soon and after couple of months I'll be able to judge (subjectively, of course) whether it really is more efficacious than Nodict.

Purely on visual basis, Naltima looks "dirtier" (more intense and deeper brownish color than what can be seen in the broken Nodict). Super pure Naltrexone should be white (like morphine). I don't actually know where the color of both preparations comes from. Could be contaminants, could be additives. On rare occasions, contaminants do create, in effect, a different drug... Things can be very complicated - let's not rush to judgment.

This is a matter of risk. The risk is simply too high to assume Nodict is a safe medication to use with TSM, given the information we currently have in front of us. Putting your faith in Nodict would be like bungee jumping with a cord you suspect might fail. Would you jump with a bungee cord that is suspected to faile, when you had 2-3 other brand new cords sitting right there you could use instead?

Until we get someone in here with credentials along the lines of Dr. Eskapa, Dr. Sinclair, etc telling us this medication is OK to use with TSM, we need to warn our members against using it, period.

My understanding is that River Pharmacy call also sell Naltima, so this isn't a River bashing effort. I went through an edited all of the posts I've made on this topic to make sure they address Nodict only and not pointed at River as the center of this issue.

Q

How the heck did all this get started? Did someone say they were not successful with TSM because they used Nordic, and blamed it on that? I've been using this stuff for a long time, had great success "chemically" if you want to put it that way and only started drinking again because of other issues unresolved.

I have complete faith in Nordic. It's working again even though I'm still drinking: because I'm drinking through the nal. So let's not get too nuts about all this, eh?

And I agree that it's really unkind to slam Debbie for putting her two cents in - of course River is a business and they want to sell a product but I doubt they would be in business for long if they were passing on suspect drugs.

So of course everyone is free to do as they wish and to use whatever form of naltrexone they wish but I'm sticking with Nordic (I've got a ton of it and I'm not going to throw it away - it works!)

I have been searching on the internet for information about Sun Pharma and Nodict. From what I can find, everything seems legit. But I am not qualified to judge something like this, which is why, I too, would like some official and objective/independent confirmation of the composition of Nodict. I can't find anything specific about Nodict, only that it (supposedly) contains 50mg of Naltrexone Hydrochloride, but I can't find any information about the other inactive ingredients. Can anyone help with this?

That aside, I'm sure Debbie is doing her best to look after her clients here on TSM forum, it's in her best interest after all, however, I am very uncomfortable with her proposing her own coaching website in reply to a query about a medication that she is selling, and doing so without even telling us that she is one and the same person. I find that unethical.

If I question Tylenol about their medication because its not relieving my pain, I do not expect to be recommended a yoga class run by the Tynelol representitive I'm speaking to, as an answer...

Curi

I have followed this discussion with interest. If there is any substance to the theory that one brand works better than another I feel desparately sorry for those who have failed because of this. However, it seems to me that rather than brand v. brand, the problem is coated v. uncoated pills.
Whilst looking around I found this explanation which may be of interest and may also explain why nausea is a common side effect.


"Enteric-coated means a pill or other form of oral medication is layered with a protective coating. It stops the pill from dissolving in the stomach and irritating the lining, or rendering the medication ineffective. In rare instances, it is used to protect the stomach from possible harmful effects of a medication. It is most commonly used in aspirin and other non-steroidal anti-inflammatories (NSAIDs) that are known to irritate the stomach lining, but is also often used in medications or vitamins that need to dissolve in the small intestine to be absorbed properly.

The stomach lining has a low power of hydrogen (pH) level. This means that it is very acidic and can easily break down food to begin the digestive process. If a pill is enteric-coated, the pill won't break down in an acidic environment but will in an alkaline environment. This means it will dissolve in the small intestine where the pH level is above 7. The word enteric actually means referring to the intestine.

Wax, plastics, or plant fibers, such as starch, are used to make the enteric coating. Other materials that are used are certain types of shellac and fatty acids. Most of these are polymers that are either man-made or natural and won’t break down below levels of pH 5.

The use of an enteric-coated was primarily prompted by the high incidence of gastric disturbance from the use of NSAIDs. It is not just a matter of pain or discomfort, and many of the NSAIDs can cause serious problems, such as ulcers. The enteric coating can be very helpful in possibly avoiding the dangerous side effects, especially for those who take NSAIDs regularly. Enteric coating is also used in fish oil and garlic supplements to stop the capsules from dissolving in the stomach and causing foul-tasting burps.

In addition to helping to avoid irritating the stomach lining, an enteric coating can also increase what’s known as bioavailability. This means that certain vitamins and medications are absorbed more readily in the small intestine, rather than the stomach. By using an enteric coating, you increase the chances that the vitamin or medication will be absorbed properly.

Enteric-coated pill may not won’t work if the coated pill is crushed or broken. Doing this breaks the seal and exposes the contents of the pill to the stomach acid. Although it may be easier to swallow a crushed pill, you will lose the protective benefits."

I have used naltrexone from All Day Chemists with my son and have had excellent results.

Chris

Currently im using nodict, I think -Q- is being unfair here.

I'll let ye know if its any good in a few months, but i think its much the same as standard naltrexone except you are less likely to get stomach irritation due to the coating on the pill.