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 Post subject: Re: JamesCT
PostPosted: Tue Sep 28, 2010 9:26 pm 
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Joined: Tue Jul 13, 2010 8:19 am
Posts: 621
Location: USA
James, in the targeted NAL condition subjects were instructed to take NAL 1-2 hours before a high risk drinking situation. The authors stated that,
Quote:
Based on our prior findings we hypothesized that naltrexone and targeted administration would reduce the mean number of daily drinks consumed and that patients receiving targeted naltrexone would show greater reductions on this measure than the other 3 groups (ie, daily naltrexone or targeted or daily placebo)
I could not find their explanation for why they thought this to be likely. They don't mention TSM, they don't reference Sinclair but they seem to be applying TSM to this study design. A possible explanation of why targeted was more effective than daily may be receptor upregulation and alcohol deprivation effect but this is purely speculative.

I'll look up Sinclair's score later. I do have access to a major university health science library so I should be able to find it.

I'll try to PM you a PDF of the study. I would rather not post it here since it may be considered a copyright infringement since it is not free access yet.

_________________
Began TSM 7/19/10 Pre-TSM 50-70 US (106UK/84AU)
Ave. units/4 weeks for 1 year (#AF/4 wks) 22.8(1AF),29(0),30(1),27(2),23(2),20(6),16(8),17(9),13(12),15.5(9),15.8(11),15.1(10),14.6(11)
regained control wk 33


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 Post subject: Re: JamesCT
PostPosted: Wed Sep 29, 2010 2:20 am 
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Joined: Tue Jun 02, 2009 11:14 am
Posts: 317
I can find no citations in the medical literature for Eskapa
Sinclair has quite a lot - my quick survey suggests he has a h-index of 23, which I guess is reasonable for someone in the medical field (where citation tends to be very high)

His 'main' paper, i.e. "Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: A factorial double-blind, placebo-controlled trial
" (2001 Journal of Clinical Psychopharmacology 21 (3), pp. 287-292) has been cited 102 times

FWIW, here they are:

References

Garbutt, J. C. (2010). Efficacy and tolerability of naltrexone in the management of alcohol dependence. Current Pharmaceutical Design, 16(19), 2091-2097. Retrieved from www.scopus.com
Foa, E. B., & Williams, M. T. (2010). Methodology of a randomized double-blind clinical trial for comorbid posttraumatic stress disorder and alcohol dependence. Mental Health and Substance use: Dual Diagnosis, 3(2), 131-147. Retrieved from www.scopus.com
Ray, L. A., Chin, P. F., & Miotto, K. (2010). Naltrexone for the treatment of alcoholism: Clinical findings, mechanisms of action, and pharmacogenetics. CNS and Neurological Disorders - Drug Targets, 9(1), 13-22. Retrieved from www.scopus.com
Chatterjee, S., & Bartlett, S. E. (2010). Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. CNS and Neurological Disorders - Drug Targets, 9(1), 60-76. Retrieved from www.scopus.com
Greenfield, S. F., Shields, A., Connery, H. S., Livchits, V., Yanov, S. A., Lastimoso, C. S., et al. (2010). Integrated management of physician-delivered alcohol care for tuberculosis patients: Design and implementation. Alcoholism: Clinical and Experimental Research, 34(2), 317-330. Retrieved from www.scopus.com
Brown, E. S., Carmody, T. J., Schmitz, J. M., Caetano, R., Adinoff, B., Swann, A. C., et al. (2009). A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. Alcoholism: Clinical and Experimental Research, 33(11), 1863-1869. Retrieved from www.scopus.com
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Davidson, D., Wirtz, P. W., Gulliver, S. B., & Longabaugh, R. (2007). Naltrexone's suppressant effects on drinking are limited to the first 3 months of treatment. Psychopharmacology, 194(1), 1-10. Retrieved from www.scopus.com
Karhuvaara, S., Simojoki, K., Virta, A., Rosberg, M., Löyttyniemi, E., Nurminen, T., et al. (2007). Targeted nalmefene with simple medical management in the treatment of heavy drinkers: A randomized double-blind placebo-controlled multicenter study. Alcoholism: Clinical and Experimental Research, 31(7), 1179-1187. Retrieved from www.scopus.com
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Petrakis, I. L., Nich, C., & Ralevski, E. (2006). Psychotic spectrum disorders and alcohol abuse: A review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram. Schizophrenia Bulletin, 32(4), 644-654. Retrieved from www.scopus.com
Green, A. I. (2006). Treatment of schizophrenia and comorbid substance abuse: Pharmacologic approaches. Journal of Clinical Psychiatry, 67(SUPPL. 7), 31-35. Retrieved from www.scopus.com
Ait-Daoud, N., Malcolm Jr., R. J., & Johnson, B. A. (2006). An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants. Addictive Behaviors, 31(9), 1628-1649. Retrieved from www.scopus.com
Roozen, H. G., de Waart, R., van der Windt, D. A. W. M., van den Brink, W., de Jong, C. A. J., & Kerkhof, A. J. F. M. (2006). A systematic review of the effectiveness of naltrexone in the maintenance treatment of opioid and alcohol dependence. European Neuropsychopharmacology, 16(5), 311-323. Retrieved from www.scopus.com
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Mattson, M. E., & Litten, R. Z. (2005). Combining treatments for alcoholism: Why and how? Journal of Studies on Alcohol, 66(SUPPL. 15), 8-16. Retrieved from www.scopus.com
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Kranzler, H. R., Armeli, S., Feinn, R., & Tennen, H. (2004). Targeted naltrexone treatment moderates the relations between mood and drinking behavior among problem drinkers. Journal of Consulting and Clinical Psychology, 72(2), 317-327. Retrieved from www.scopus.com
Cowen, M. S., Chen, F., & Lawrence, A. J. (2004). Neuropeptides: Implications for alcoholism. Journal of Neurochemistry, 89(2), 273-285. Retrieved from www.scopus.com
Oswald, L. M., & Wand, G. S. (2004). Opioids and alcoholism. Physiology and Behavior, 81(2), 339-358. Retrieved from www.scopus.com
Vaughn, M. G., & Howard, M. O. (2004). Integrated psychosocial and opioid-antagonist treatment for alcohol dependence: A systematic review of controlled evaluations. Social Work Research, 28(1), 41-55. Retrieved from www.scopus.com
Kiefer, F., Jahn, H., Holzbach, R., Briken, P., Stracke, R., & Wiedemann, K. (2003). The NALCAM-study: Efficacy, tolerability, outcome. [Die NALCAM-studie: Wirksamkeit, verträglichkeit, outcome] Sucht, 49(6), 342-351. Retrieved from www.scopus.com
Mason, B. J. (2003). Acamprosate and naltrexone treatment for alcohol dependence: An evidence-based risk-benefits assessment. European Neuropsychopharmacology, 13(6), 469-475. Retrieved from www.scopus.com
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Mark, T. L., Kranzler, H. R., & Song, X. (2003). Understanding US addiction physicians' low rate of naltrexone prescription. Drug and Alcohol Dependence, 71(3), 219-228. Retrieved from www.scopus.com
O'Malley, S. S., Rounsaville, B. J., Farren, C., Namkoong, K., Wu, R., Robinson, J., et al. (2003). Initial and maintenance naltrexone treatment for alcohol dependence using primary care vs specialty care: A nested sequence of 3 randomized trials. Archives of Internal Medicine, 163(14), 1695-1704. Retrieved from www.scopus.com
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Gastfriend, D. R. (2003). Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: Rationale and methods. Alcoholism: Clinical and Experimental Research, 27(7), 1107-1122. Retrieved from www.scopus.com
Friedlander, A. H., Marder, S. R., Pisegna, J. R., & Yagiela, J. A. (2003). Alcohol abuse and dependence: Psychopathology, medical management and dental implications. Journal of the American Dental Association, 134(6), 731-740+742. Retrieved from www.scopus.com
Bentley, K. W. (2003). β-Phenylethylamines and the isoquinoline alkaloids. Natural Product Reports, 20(3), 342-365. Retrieved from www.scopus.com
Kranzler, H. R., Armeli, S., Tennen, H., Blomqvist, O., Oncken, C., Petry, N., et al. (2003). Targeted naltrexone for early problem drinkers. Journal of Clinical Psychopharmacology, 23(3), 294-304. Retrieved from www.scopus.com
Anton, R. F., & Swift, R. M. (2003). Current pharmacotherapies of alcoholism: A U.S. perspective. American Journal on Addictions, 12(SUPPL. 1), S53-S68. Retrieved from www.scopus.com
Soyka, M., & Chick, J. (2003). Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: A european perspective. American Journal on Addictions, 12(SUPPL. 1), S69-S80. Retrieved from www.scopus.com
McAlister, F. A., Straus, S. E., Sackett, D. L., & Altman, D. G. (2003). Analysis and reporting of factorial trials: A systematic review. Journal of the American Medical Association, 289(19), 2545-2553. Retrieved from www.scopus.com
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Kiefer, F., Jahn, H., Tarnaske, T., Helwig, H., Briken, P., Holzbach, R., et al. (2003). Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: A double-blind, placebo-controlled study. Archives of General Psychiatry, 60(1), 92-99. Retrieved from www.scopus.com
Gastpar, M., Bonnet, U., Böning, J., Mann, K., Schmidt, L. G., Soyka, M., et al. (2002). Lack of efficacy of naltrexone in the prevention of alcohol relapse: Results from a german multicenter study. Journal of Clinical Psychopharmacology, 22(6), 592-598. Retrieved from www.scopus.com
Bodnar, R. J., & Hadjimarkou, M. M. (2002). Endogenous opiates and behavior: 2001. Peptides, 23(12), 2307-2365. Retrieved from www.scopus.com
Saunders, J. B., & Brady, K. T. (2002). The scientific basis for the prevention and treatment of substance misuse. Current Opinion in Psychiatry, 15(3), 231-234. Retrieved from www.scopus.com
Schmidt, L. G. (2002). Advances in the treatment of alcohol dependence. Current Opinion in Psychiatry, 15(3), 255-260. Retrieved from www.scopus.com
Fuller, R. K., & Gordis, E. (2001). Naltrexone treatment for alcohol dependence. New England Journal of Medicine, 345(24), 1770-1771. Retrieved from www.scopus.com

_________________
Pre-TSM, ~105 (UK) Units, ~0.5 AF days, Craving 8
Wk 1-8 93/0.25/3.5
Wk 9-16 79.5/0.5/2.8
Wk 17-24 75/1.2/2.7
Wk 25-32 61.5/2.3/1.6
Wk 33-40 47/3.5/1.1
Wk 41-48 47/3.5/1
Wk 49-56 44/3.8/1
Wk 57-64 45/3.8/1
Wk 66 45/3/1
Wk 66 65/1/1
Wk 67 48/3/1


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 Post subject: Re: JamesCT
PostPosted: Wed Sep 29, 2010 2:51 am 
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Joined: Tue Jun 02, 2009 11:14 am
Posts: 317
hmmmmm

one of Sinclairs references is a letter to the New England Journal of Medicine, which is co-signed by a Dr. Marc Shinderman of Illinois. I just did a quick search on the latter to see if he had any publications supporting TSM. An interesting result to say the least!

Shinderman appears to have several felony convictions in different states :shock:
http://www.healthgrades.com/directory_s ... ound-check

Now I don't want to damn Sinclair by association, and admittedly the above felonies occur some 5 years after the letter to the NEJM, but it still gave me pause for thought. Some details of the cases are posted here:
http://nama-president.blogspot.com/2006 ... chive.html
which admittedly makes it sound more benign than might be imagined at first.

_________________
Pre-TSM, ~105 (UK) Units, ~0.5 AF days, Craving 8
Wk 1-8 93/0.25/3.5
Wk 9-16 79.5/0.5/2.8
Wk 17-24 75/1.2/2.7
Wk 25-32 61.5/2.3/1.6
Wk 33-40 47/3.5/1.1
Wk 41-48 47/3.5/1
Wk 49-56 44/3.8/1
Wk 57-64 45/3.8/1
Wk 66 45/3/1
Wk 66 65/1/1
Wk 67 48/3/1


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 Post subject: Re: JamesCT
PostPosted: Wed Sep 29, 2010 5:14 pm 
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Joined: Fri Jul 30, 2010 11:07 am
Posts: 66
Yeah seems pretty minor- probably common practice, just never exposed


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 Post subject: Re: JamesCT
PostPosted: Fri Oct 01, 2010 1:34 am 
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Joined: Wed Jan 06, 2010 7:05 am
Posts: 159
.


Last edited by DOMD on Sat Dec 24, 2022 3:55 pm, edited 1 time in total.

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 Post subject: Re: JamesCT
PostPosted: Fri Oct 01, 2010 5:31 pm 
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Joined: Thu Feb 11, 2010 6:32 pm
Posts: 472
DOMD
I agree, but most folk come in here in the depths of alcoholism and what they are most looking for is support and a bit of hope having heard of tsm. James knocked tsm from get go even though he claimed to be on board, and he even claimed to see benifits from it!?

Yes I agree we have to ask questions but at the end of the day this is a support site for people on the sinclair method. There are more people here that just want to come and log their progress and gain a bit of insight from others that have been here for a few weeks than there are people who want to know the exact science behind it.

Personally I have read everything I could find about TSM but not everybody wants to do that.Right now Im thinking of someone who Ive indroduced to the site. TSM works no matter whether you want to know how it does it or not.

I would love to start a thread here about how much tsm has helped people EVEN if they believe they have NOT beencured. Has it helped? Are they drinking less


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 Post subject: Re: JamesCT
PostPosted: Fri Oct 01, 2010 8:45 pm 
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Joined: Wed Jan 06, 2010 7:05 am
Posts: 159
.


Last edited by DOMD on Sat Dec 24, 2022 3:56 pm, edited 1 time in total.

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 Post subject: Re: JamesCT
PostPosted: Fri Oct 01, 2010 9:16 pm 
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Joined: Tue Mar 09, 2010 10:39 pm
Posts: 626
DOMD, the thing is, nobody ever said he shouldn't question. never. He was just such an ass about it, and he made insulting statements and condescended. He didn't just say "there's not enough evidence" he said "there;s no proff that TSM works...none" no way he was doing TSM! the guy was just some troll. I think there should be more studies too. I'm all for putting the screws to these guys and getting whatever information there is. Tonight I asked Eskapa to post the updated database on clinical studies in humans he promised in the "Dr. sinclair's response to JamesCT" thread. (that's not really the name of the thread) but it's in the general discussion if you haven't seen it.

he ran off goodman too. i, like mario was also thinking about people i've pointed to this site. In fact, in the last 4 days, I've had 2 people interested and asking me about it. I didn't give either one a link here like i normally would've. sad. not saying we shouldn't question, but why come here and constantly attack? I think he ran off goodman too! I hope he's ok

If I went to an AA forum and did nothing but attack AA and say that AA doesn't work, I would understand being met with a chilly response, even banned. but no, he wasn't banned. he was even encouraged to question. and when Eskapa confronted him on it he turned tail and ran like a good little troll.

glad you're still doing well DOMD. lets keep looking for more evidence, keep questioning.

meanwhile I say we let this troll's thread die a natural death. there is a good thread by eskapa in general discussion about proof and studies. a good place where we can question and look for answers. the thread in which the troll signed off before Eskapa posted the follow up database he promised :D James didn't want answers.

don't post here unless you want to revive a devisive, lamo thread.

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 Post subject: Re: JamesCT
PostPosted: Sat Nov 20, 2010 5:25 am 
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Joined: Tue Oct 05, 2010 10:14 pm
Posts: 167
Where did this guy go?


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 Post subject: Re: JamesCT
PostPosted: Sat Nov 20, 2010 7:09 am 
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Joined: Tue Jul 13, 2010 8:19 am
Posts: 621
Location: USA
MWO forums, "37 degrees" is his name over there.

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Began TSM 7/19/10 Pre-TSM 50-70 US (106UK/84AU)
Ave. units/4 weeks for 1 year (#AF/4 wks) 22.8(1AF),29(0),30(1),27(2),23(2),20(6),16(8),17(9),13(12),15.5(9),15.8(11),15.1(10),14.6(11)
regained control wk 33


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