I was told by Eskapa that he's seen folks do well by upping their dosage to 75mg after being on TSM a while. I am almost 3 months in and am doing just that. He told me to check with my doctor first of course, and stressed that 300mg in 24hrs is the max allowed before it can mess with the liver. I thought i'd start a thread about this as I haven't seen anything about upping to 75mg.

I upped it because I have no side effects anymore, had very few to begin with, and really really want this to work.

Joe,

Thanks for posting this as I guess Eskapa is still testing this 25 mg 6-12 hours later? I've actually done this and I think it makes a difference.

I think tonight would've been one of those nights but I am almost ready for bed and am not drinking more than one more unit in eight hours after my dosage of Nal....

Still Struggling (9 months), My Best, Jim

well I asked about taking another one during a long drinking session and he said take another 50mg after 10 hours. but he said in addition to that, upping to 75mg for the original dose could be beneficial. said more isn't necessarily better but it's worked for some, while 25mg has worked for others.

After 6 months with no change, my Dr upped my doseage to 100 mgs. Stayed there for 6 months with no changes. Went back to 50 and now going to drop NAL altogether and just stay on Baclofen. I had major flashes & night sweats at 100 mgs...but no other significant SEs. Good luck!