This topic has been discussed quite a bit on this board. There are many threads. Here's a link to a thread for which I wrote a very long post about the pros and cons of adding baclofen to TSM.
http://www.thesinclairmethod.net/commun ... 3b38aa46cbTo my earlier post on this thread, I'd add these observations: First, in the nearly-a-year since I wrote that post, many, many more folks posting on MyWayOut have found success through baclofen. I also believe more is appearing in scientific literature about treating alcoholism with baclofen, although much of it appears to be case studies as opposed to clinical trials (although these are certain to show up in time). Some here have found success by adding baclofen to TSM after experiencing a stall in progress with naltrexone alone. The baclofen/naltrexone combo seems to be a popular method at MyWayOut. Many use it as an alternative to the prospect of long-term or even lifelong baclofen. Topamax seems to be enjoying a revival, and one member here (MissKris) reported a good result with a topamax/naltrexone combo.
As I searched for this link, I noticed that a few members here who were thinking about adding baclofen ended up being patient getting a great result on naltrexone alone. Still, baclofen remains an exciting alternative for those unfortunate few unable to achieve the desired result with TSM. As Craving has said, baclofen saves lives.
The exciting part of all this is that we have choices where before there were none. (I personally don't count AA as a choice). Thank God for the pioneers such as R Jewell (MWO founder), Amiesen, the HAMS people, and of course Sinclair and Eskapa for providing us with these choices. With these choices comes the responsibility to be scrupulously well-informed. As I say in the linked post, combining baclofen and alcohol (or topamax) is a dicey proposition, not to be taken lightly.