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 Post subject: Re: I just struck gold!!!!
PostPosted: Tue Sep 29, 2009 7:15 pm 
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Location: Connecticut
Sounds good. Trouble is, we're not bred as specific strains of lab rats so we all differ enormously.

Nonetheless, this may be an investigation to follow and seriously consider. As well as informing the medical community...

Problem is, how do you do that in the current negatively-scrambled lobbyist environment?

Mike


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 Post subject: Re: I just struck gold!!!!
PostPosted: Wed Sep 30, 2009 9:22 am 
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minneapolisnick wrote:
Evan, can you help me with this? Which studies directly test TSM as a theory, as in, which studies involve subjects who were specifically told, "take naltrexone one hour before you drink and then drink as you normally would"?


There aren't many. The best are the Finnish ones.

I have found like 3 so far I think (studies using the "targeted" protocol, independent of the research done in Finland by Sinclair and others). I'm dropping them in a directory for you and I'll send them you're way when I think I've got them all. One of them involves 21 patients. It was successful, and the results were significant, but come on...21 subjects?

There are many in which the targeted protocol was not employed but for which the results implicate that it should be. There are also a few in which the targeted protocol was not employed but the researchers directly concluded that extinction was the mechanism of action.

I am going to look into the clinics (eg the one in Florida) to see if they keep some kind of statistics, when I get a chance, as I think this might be a good place to find some more info. As it stands though, nothing holds as much power as the DBPC's done in Finland.

edit: Actually none of them use the targeted protocol, and the instructions to "drink as you normally would." The ones that I've found that use the targeted protocol tell them to take the Naltrexone in a high risk situation.

Again the clinical stats that may exist, although not scientifically controlled, are where you'd find more results of TSM actually being employed. I'll look for 'em...the idea came to me yesterday after reading your question.

_________________
Graph Of My Units Over 182 Days

Weeks 0-26: 80, 65, 97, 90, 80, 101, 104, 83, 83, 88, 91, 83, 100, 39, 32, 71, 51, 34, 4.5, 0, 5, 3, 6, 11, 0, 0, 0u

I'll always naltreksonipillerin advance

---Lo0p (resident geek :roll: )


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 Post subject: Re: I just struck gold!!!!
PostPosted: Wed Sep 30, 2009 10:44 am 
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Thanks, great work. It's nice to have an enthusiastic, highly-capable researcher on the job. ;)

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Pre-TSM:50+wk/hangovers/blackouts/bad behavior
Regained Control wk36
Now:<20/wk/NO hangovers/blackouts/bad behavior
(Nothing in this post should be construed as medical/legal advice. Always consult a physician before taking prescription drugs.)


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 Post subject: Re: I just struck gold!!!!
PostPosted: Tue Oct 06, 2009 11:05 am 
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I just got in touch with Beverly Rayfield from the clinic in Florida. They do keep statistics and she's sending them my way :D

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Graph Of My Units Over 182 Days

Weeks 0-26: 80, 65, 97, 90, 80, 101, 104, 83, 83, 88, 91, 83, 100, 39, 32, 71, 51, 34, 4.5, 0, 5, 3, 6, 11, 0, 0, 0u

I'll always naltreksonipillerin advance

---Lo0p (resident geek :roll: )


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 Post subject: Re: I just struck gold!!!!
PostPosted: Tue Oct 06, 2009 11:08 am 
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WaitingToExhale wrote:
Nice job Loop! Can't wait to see them! WHOO HOO! Email or snail mail?



Email I hope...

_________________
Graph Of My Units Over 182 Days

Weeks 0-26: 80, 65, 97, 90, 80, 101, 104, 83, 83, 88, 91, 83, 100, 39, 32, 71, 51, 34, 4.5, 0, 5, 3, 6, 11, 0, 0, 0u

I'll always naltreksonipillerin advance

---Lo0p (resident geek :roll: )


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 Post subject: Re: I just struck gold!!!!
PostPosted: Tue Oct 06, 2009 1:17 pm 
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Joined: Fri Feb 06, 2009 11:00 am
Posts: 579
Location: England, UK
Lo0p wrote:
minneapolisnick wrote:
Evan, can you help me with this? Which studies directly test TSM as a theory, as in, which studies involve subjects who were specifically told, "take naltrexone one hour before you drink and then drink as you normally would"?

I am going to look into the clinics (eg the one in Florida) to see if they keep some kind of statistics, when I get a chance, as I think this might be a good place to find some more info.

Again the clinical stats that may exist, although not scientifically controlled, are where you'd find more results of TSM actually being employed. I'll look for 'em...the idea came to me yesterday after reading your question.

Hi Lo0p,

I, like others, am interested in whatever data you are able to obtain. Indeed, it almost certainly will be of interest to all TSMers.

All the best.

V.

_________________
Weekly Consumption
Wk01-10: 86, 98, 103, 104, 97, 92, 102, 103, 102, 107
Wk11-20: 100, 99, 100, 105, 108, 108, 89, 95, 105, 97
Wk21-30: 97, N/R, N/R, 97, 105, N/R, N/R, 107, 97, 98
Wk31-40: 93, 88, 87, 87, 91, 92, 94, N/R
UK units
N/R = Not Recorded


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 Post subject: Re: I just struck gold!!!!
PostPosted: Thu Oct 08, 2009 7:19 pm 
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Still waiting on Beverly Rayfield for her stats...

Here's a new study that's not finished yet where they haven't screwed up the proper protocol so bad that they might actually see some results:

http://clinicaltrials.gov/ct2/show/NCT00920829?term=Naltrexone+AND+Alcohol&rank=26

_________________
Graph Of My Units Over 182 Days

Weeks 0-26: 80, 65, 97, 90, 80, 101, 104, 83, 83, 88, 91, 83, 100, 39, 32, 71, 51, 34, 4.5, 0, 5, 3, 6, 11, 0, 0, 0u

I'll always naltreksonipillerin advance

---Lo0p (resident geek :roll: )


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 Post subject: Re: I just struck gold!!!!
PostPosted: Thu Oct 08, 2009 7:23 pm 
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Ooh! Here's a good one maybe:
http://clinicaltrials.gov/ct2/show/NCT00369408?term=Naltrexone+AND+Alcohol&rank=28

Too bad they haven't published the results yet.

_________________
Graph Of My Units Over 182 Days

Weeks 0-26: 80, 65, 97, 90, 80, 101, 104, 83, 83, 88, 91, 83, 100, 39, 32, 71, 51, 34, 4.5, 0, 5, 3, 6, 11, 0, 0, 0u

I'll always naltreksonipillerin advance

---Lo0p (resident geek :roll: )


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 Post subject: Re: I just struck gold!!!!
PostPosted: Thu Oct 08, 2009 7:30 pm 
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Joined: Sat Jul 18, 2009 1:40 pm
Posts: 749
Ooh! Here's another good one...with an interesting twist (lucky guys ;) ):
http://clinicaltrials.gov/ct2/show/NCT00444418?term=Naltrexone+AND+Alcohol&rank=40

_________________
Graph Of My Units Over 182 Days

Weeks 0-26: 80, 65, 97, 90, 80, 101, 104, 83, 83, 88, 91, 83, 100, 39, 32, 71, 51, 34, 4.5, 0, 5, 3, 6, 11, 0, 0, 0u

I'll always naltreksonipillerin advance

---Lo0p (resident geek :roll: )


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 Post subject: Re: I just struck gold!!!!
PostPosted: Thu Oct 08, 2009 8:00 pm 
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Joined: Mon Sep 14, 2009 2:53 pm
Posts: 511
Location: Massachusetts
Quoting

"Actually none of them use the targeted protocol, and the instructions to "drink as you normally would." The ones that I've found that use the targeted protocol tell them to take the Naltrexone in a high risk situation."

And does that mean that many of them would maybe not drink, hence not encouraging extinction? High risk doesn't necessarily mean you drink. Its like a movie where the love story interests are trying to meet and miss each other by minutes only to be misinterpreted by each as being stood up. This is the way i feel as I read and hear about the misuse and misprescribing of Nal....Sheesh

I was in a very high risk with my wife and two of her colleagues. Her colleague had a margarita as did my wife and the husband of her had a Chimay Ale (quite the taste). Anyways, I drank club soda lemon and lime cuz sweetie won't let me drink cuz I'm an alkie. Anyways, can you imagine, if I took Nal and didn't drink, got pissed off the next day, resented the situation and then drank without Nal....it could be a horrible spiral downward with opiod upregulation......making the craving for alcohol worse!

These waters are more charted than the regular populous knows yet its like a secret. I'm so glad one of our members is posting on craig's list. We need to as I've stated in the next year, cull all the cured folk and have a convention and do a media blitz,...why haven't the Finns? How is Dr. Eskapa's book selling? There has to be #'s. Dr Eskapa...Paging Dr. Eskapa...Are you selling millions?


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