Hello, I am new & feeling desperate.

I have been using TSM for a week now. I take 50mg 1 hr before drinking. Pour a glass of wine and immediately feel the same warmth and feel goods that make me want to pour another... and another... and by the end of the evening the bottle of wine is gone and I'm debating opening another. This has happened to me every time I take Naltrexone (and obviously when I don't). The medicine has had zero effect on the endorphines I receive from drinking. Has anyone else experienced this? By all accounts people say it curbs their drinking, but I honestly feel no difference. Except for maybe a little nausea. Today I'm suffering a bad hangover today after taking Naltrexone (waiting 1 hr) and drinking too much last night. Again. Any suggestions? I was really hoping that this would help me. Other attemps to stop or curb drinking have failed. Also, could it have something to do w/the fact that I take Zoloft (SSRI)? It's the only thing I can think of that might be blocking the Naltrexone from working properly. Anyhow, thank you for your forum and for listening and hopefully responding.

Hi, Bodhi. I answered you on the OSL forum:

Hi, Bodhi. I merged your two posts since they seemed identical. Things can get a bit quiet here on the weekend, but there are lots of members here ready and willing to assist. As 'case' explained NAL affects different people different ways. You mention that you have felt a bit of nausea. Further, that your hangovers are intensified. That said we have every reason to believe the medication is working in some capacity. So otherwise you've noticed no difference what so ever in the quality of the buzz? Has there been any change? In the text, 'The Cure for Alcoholism' it is highlighted there's a small subset for whom NAL doesn't work for. I know it stated they don't like sweet solutions and something else that's escaping me. Regardless, having been on here for two years I've seen countless newbies concerned it's not working only to stick with it and find it in fact does. One thing you could try as an experiment is taking 75mg and see if there's any difference - for most people there's absolutely no reason to do this as 100s of studies have found 50mg to be the optimal dose.

There is no conclusive evidence one way or the other how SSRIs affect TSM never mind individuals as it relates to alcohol consumption. For example, in my late twenties I was prescribed Zoloft and it took my drinking to whole new levels. Most notably I began watching the clock for 5pm and soon moved the activity up to 4pm. Years later a psychiatrist, who thought the whole SSRI thing was a for-profit gimmick anyway, told me that drinking alcohol on Zoloft instantly negates any possible benefit the medication can offer. That said I don't know what to tell you about that other than I've yet to read any account factually determining that Zoloft prevented the effectiveness of NAL. FYI, I went on Wellbutrin as I began TSM and had very good results. So much so that I no longer take pharma drugs (but for NAL if/when I consume).

Thank you. ❤️