The drug called "Contrave" is being hyped to be the magic pill in weight loss. It recently successfully passed Phase III trial and is up (or will be very soon) for the FDA approval as a prescription medicine. It is an extended release version of a combination of two well-known drugs, Naltrexone and Bupropion (AKA Wellbutrin, AKA Zyban). As many here may know, Zyban is by far the most effective and safe medicine prescribed for smoking cessation and Wellbutrin is a somewhat inefficient but very safe antidepressant. Apparently, people on all versions of Bupripion tend to lose weight in the beginning but then gain it again. It is suggested that when Naltrexon is added to the mix, it suppresses cravings for food.

I think it can be said that this is a case of TSM or pharmacological extinction - you eat while taking Naltrexon to help you deal with the urges to eat! Interestingly, the company that makes Contrave suggests that it is an extended release version of both that is critical for the success of Contrave.
Maybe, just maybe it means people here will be better off taking NAL in 25 mg portions during the drinking session (?).

Just google "contrave" and read away. It should be easy to find the clinical trial reports. It's a pity it seems no one ever tried combination of naltrexone and wellbutrin on alcoholic patients. Maybe soon?