jaba wrote:
Summerglow,
I am happy to hear about your progress, and I am glad you found that Nalmefene is working for you (getting past the side effect I hear can be brutal). I did a quick search and it seem the Nalm. works on the smaller receptors (per one research page) and this article claims it hits the different opioid receptors:
The first medication developed for the treatment of alcohol dependence was naltrexone, an opioid receptor blocker. At therapeutic doses, it blocks most of the mu subtype of opioid receptors in the brain but it has lesser effects at the delta and kappa subtype of opioid receptors. Nalmefene is a newer opioid receptor modulator that has a subtly different profile at opioid receptor subtypes, with increased relative potency for kappa opiate receptors compared to its potency at mu opiate receptors. It was studied here because it has been shown to have potential for reducing alcohol consumption.
"It remains to be seen whether the differences between nalmefene and naltrexone at opioid receptors yield meaningful differences in their effectiveness," cautioned Krystal.http://www.news-medical.net/news/201304 ... ients.aspxIt is still a little technical maybe someone can explain it in simpler terms,
Jaba
Thank you for that, and I sort of understand. The side effects were bad, but I had an ear infection at the same time, so I can't really blame all on the Nalm.
I'm still pouring the rest down the sink, so all good...but, what a waste of money, butyou do what you have to do!
Summer