Good Morning!

Hopefully someone can answer this morning, can I take Excedrin? I just started taking Nal two days ago.

Thanks, Zip

Hi Zippy,

You probably haven't gotten any answers because nobody knows the answer. If it is an opioid then Naltrexone will interfere with it, this is one of the few disadvantages of Naltrexone, it will reduce or block the effect of opioid pain medication, so if we are in a situation where we need opioids for pain management we need to tell our doctors that we are taking Naltrexone so they can increase the dosage or switch to another type of pain relief.

From what I understand it is paracetamol so you should be ok, but the best thing to do would be to ask a doctor.

Curi.

[The following is merely my opinion and is in no way a medical advice]

Yes, but carefully. Exedrin is acetaminophen (Tylenol)+aspirin+caffeine. None of these, strictly speaking, interacts with naltrexone. The only advice/warning given is in regard to hepatotoxicity. Nal, acetaminophen and alcohol are all known to be toxic to liver (the degree depends on doses and individual genetics). So taking them together always has a potential to damage liver (and the same effect pertains to every other drug, basically). If you never had any issues with them separately and if you don't take them together in large doses and/or regularly then you are very unlikely to any serious problems. (Consider, for example, how many people drink and take Tylenol or Ibuprophen even though the combination is known to be quite toxic to liver). In any case, having an annual liver enzymes blood test is always a very good idea! Caveat: if you ever had any issues with liver, then none of the above reasonably applies and you absolutely need doctor supervision to make sure that whatever you take is not literally killing your liver.

There is another potential issue of whether caffeine in Exedrin would interfere with Nal's effectiveness in TSM. Here the answer is definitive: no one has any clue. If Nal works for you while drinking three cups of strong coffee daily then you should have no problem with Exedrin. But the same would not necessarily apply to others.

My doc said basically any of those aspirin type meds (aspirin, but also acetomephen and ibuprofen) are fine, in normal quantities, with nal.

Thanks! Well understood.