I have a number of questions about this.

- It seems to me that information about the clinical trials that Sinclair, himself, did would be available for docs to examine. Is this the case? If so, how would one find this information.

- When I look at the JAMA article referenced in the book about the COMBINE study (http://jama.ama-assn.org/cgi/content/full/295/17/2003) I don't see reference to the conclusion that one must drink on naltrexone. Am I being blind? Will the doc see what I am not seeing?

I am starting to find it really weird that I cannot find clinical trial information on the internet. I am seeing what claims to be FDA information on the subject and see this

http://www.drugs.com/pro/naltrexone.html

I am not seeing much about the clinical trials to suggest the miracle that TSM claims. The thing that strikes me the funniest is that the warning is very firm that opiates should not currently be being used for opiate addiction treatment. This seems completely backward. It also tells you to take 50mg daily....

I find myself confused by the information I am seeing. Can anyone help me find clinical trials that demonstrate TSM as effective?

Thanks

S

http://alcalc.oxfordjournals.org/cgi/reprint/36/1/2

I'm not sure if this is what you're asking for, but I think you can download a PDF of Sinclair's paper here. Let me know if you have trouble opening it.

Thank you. This is helpful.

Hello, new to this site and excited about the info/support available. I have a doc who is willing to prescribe whatever I want...sounds great but.....she really doesn't know much about the method and I find myself frustrated and looking for answers she cannot provide. Have been on Nal since April of this year and had a significant decrease early on but not cured. I need this forum to help me understand and accept the slow progress. I would like to find a doc who knows the method and can support and prescribe... Any advice???

cautiouslyoptimistic,

COMBINE study did not use TSM, period. "Proper" references on TSM that are likely to be taken seriously by your doc are few and far in between:

1. http://www.ncbi.nlm.nih.gov/pubmed/11386491
(It's actually not quite TSM but close enough).
2. http://www.ncbi.nlm.nih.gov/pubmed/19593174
3. http://www.ncbi.nlm.nih.gov/pubmed/16634855

There are no clinical trials to support the miracle claims but these are the studies that suggest that TSM is at least on a par with other conventional treatments. There are also common sense reasons to believe that "pharmacological exctinction" with naltrexone can work. And, there are very convincing experiments on mice that "prove" TSM principle. So with your doc press on giving this option a fair chance since you have already tried other options and will still try others if TSM won't work. If your doc is any good, he/she should accept the validity of this reasoning.