So happy for you, Magda! It sounds like you're in it for the long haul, too.

We probably have fewer than average.

I suppose you could get a smidgen of upregulation this way. I wouldn't expect this upregulation to be permanent, though. IIRC, the short-term upregulation from taking the full dose only lasts a couple of days.

Doing it slowly and gradually might be different, though. I'll be interested to hear Magda's results. How do you plan to measure, Magda?

I don't think there's any way to accurately measure receptor up-regulation (aside from dissecting my brain like all those poor rats), but I thought I would just try it for a while and see if I get a general mood increase or increased pleasure from endorphin-generating substances (e.g. chocolate) and activities (e.g. exercise). If there is a good result, it will still be impossible to distinguish it from my brain healing on its own. Too bad I don't have a clone to use as a control. Scratch that, she'd probably annoy me. I'll keep you guys posted anyway. I don't see much risk, other than what sideeffect mentioned, which is non-trivial, but acceptable to me.

I hypothesize that it might be a quicker way to get my receptors back to baseline after all the years of hammering them with alcohol. I haven't read anything about the short-term up-regulation after 50 mg, nor have I read about what happens when stopping the low-dose naltrexone. From what I've read, improvements are slow (months to years), but I don't know if they are permanent. It seems plausible that the up-regulation back to baseline would be permanent, but unreasonable to expect much beyond that. Trouble is, I don't really remember my baseline, since I've been drinking heavily since my mid-teens.

I should mention for anyone else that wants to try it that you should keep the solution in the fridge and shake it before you use it. The shaking may not be necessary, since I think just the filler from the pill doesn't dissolve, but there is powder in the bottom of my little bottle.

Woot, woot! Magda, you have been an inspiration. I'm happy to see you are a quick responder and that you are doing so well. Please keep posting. Keek

Congrats!! I hope to be right behind you in a few months!

Way to go Magda! That is so exciting and I am so happy for you.
I look forward to hearing your continued journey with your new outlook and new life! Congratulations.