*
It is currently Mon Jan 25, 2021 7:53 pm

All times are UTC - 6 hours




Post new topic Reply to topic  [ 3 posts ] 
Author Message
 Post subject: Duration of Occupancy of Opiate Receptors by Naltrexone
PostPosted: Fri May 01, 2009 11:13 pm 
Offline
User avatar

Joined: Thu Mar 19, 2009 10:44 am
Posts: 71
Hello Dr. Eskapa,

During the past few weeks, I've discovered that a 25mg dose of Naltrexone appears to be just as effective at eliminating my desire to drink as a 50mg dose, and also dramatically reduces problematic side effects. That curious fact prompted me to research medical journals, where I stumbled across a couple of peer-reviewed articles regarding the "Duration of Occupancy of Opiate Receptors by Naltrexone" for various dosages. The results indicate 25mg of naltrexone provides a complete opioid receptor blockade for at least 12 hours -- which is more than sufficient to eliminate the endorphin rush during my typical evening beer-drinking session (between 1 and 5 hours maximum). I realize 50mg is the standard dosage recommended in The Cure for Alcoholism (and substantiated through research), but I'm wondering if that particular number is due to the fact 50mg results in an opioid blockade for a full 24-hour period -- thus ensuring the drinker is always protected -- whenever they choose to drink. Would you please comment as to whether you think my lower dosage may be detrimental to the long-term success of program -- taking into account the unique (daily/evening-only) drinking pattern I've disclosed? So far, I've had great success with TSM (better than I ever hoped!). I'm approximately 7 weeks into the program with a 60% reduction in average consumption, experienced my first AF day this past week, and have no side effects whatsoever.

_________________
Pre-TSM: 42 units (US)
Wk1-4: 29, 24, 22, 21
Wk5-8: 18, 19, 15, 17
Wk9-12: 15, 18, 13, 14
Wk13-16: 16, 14, 13, 15
Wk17-20: 14, 15, 14, 14
Wk21-24: 13, 14, 13, 14
Wk25-28: 11,


Top
 Profile E-mail  
 
 Post subject: Re: Duration of Occupancy of Opiate Receptors by Naltrexone
PostPosted: Mon May 11, 2009 6:48 pm 
Offline

Joined: Fri Feb 06, 2009 5:39 pm
Posts: 112
If you are responding well to 25 mg naltrexone 30 minutes to an hour before drinking then by all means proceed. There are individual differences in metabolism and absorption of the medication. Some doctors prescribe 100 mg naltrexone ... but the studies reported are based on 50 mg, as you said. In this case taking a larger dose will not speed up the de-addiction process. As long as the opioid receptors are blocked so that there is no reinforcement coming from the endorphins released by alcohol, then you will be extinguishing the addiction. Just as the addiction is not learned overnight so the de-addiction (pharmacological extinction) process takes time.


Top
 Profile E-mail  
 
 Post subject: Re: Duration of Occupancy of Opiate Receptors by Naltrexone
PostPosted: Thu Apr 18, 2019 2:18 am 
Offline

Joined: Thu Apr 18, 2019 2:16 am
Posts: 1
Those people who are interested to know about duration of the occupancy can get useful info about that with read of this share. Now you can easily find best dissertation help online from any place of the world on any time.


Top
 Profile E-mail  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 3 posts ] 

All times are UTC - 6 hours


Who is online

Users browsing this forum: No registered users and 1 guest


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to:  
cron
Powered by phpBB © 2000, 2002, 2005, 2007 phpBB Group