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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 6:14 pm 
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jackson_pdx wrote:
Sorry if I'm not getting it, but how does your reward center know it's the first drink or the fortieth? As soon as it gets AL in the blood, it's happy hour for it even if that alcohol was from a beer you chugged two hours ago or a shot of vodka you took five minutes ago.


Okay, my thought is that it first goes to the brain, then goes metabolic. Why else the cravings for another drink? Before the first one even got processed by the body? Maybe because the brain no longer has access?

I dunno. These are the things I can't seem to find scientific abstracts on.

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Start date 4/21/15
1st week: 10 beers. 5 days AF


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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 6:22 pm 
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Posts: 347
Location: Orange County, CA, USA
jackson_pdx wrote:
Sorry if I'm not getting it, but how does your reward center know it's the first drink or the fortieth? As soon as it gets AL in the blood, it's happy hour for it even if that alcohol was from a beer you chugged two hours ago or a shot of vodka you took five minutes ago.


Sorry, I have 0 answers, only questions. Amazing to me that an ultra low dose of NAL can apparently protect from a dose of morphine which I would assume takes some time to metabolize. And does the body see each drink as a new dose and that NEW dose is the danger, not the accumulated alc or morphine.

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Now 2 beer max per day.
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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 6:29 pm 
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Location: Orange County, CA, USA
Mason wrote:
jackson_pdx wrote:
Sorry if I'm not getting it, but how does your reward center know it's the first drink or the fortieth? As soon as it gets AL in the blood, it's happy hour for it even if that alcohol was from a beer you chugged two hours ago or a shot of vodka you took five minutes ago.


Okay, my thought is that it first goes to the brain, then goes metabolic. Why else the cravings for another drink? Before the first one even got processed by the body? Maybe because the brain no longer has access?

I dunno. These are the things I can't seem to find scientific abstracts on.


That makes some sort of sense to me. At least as to why we may be just treating the rush period. If that were the case, we would need coverage just past the point of ingestion, not till the alc is totally worn off. Your low dose might be QUITE adequate if you don't drink for an extended time period.

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Pre TSM 30-40 AF/0
Now 2 beer max per day.
On LDN (4mg Nal)


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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 6:44 pm 
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I would just like to add that it is page 43 in the book where I got my quote:

Quote:
Other behaviors reinforced by the opioid system are avoided
while on naltrexone but occur on days when no naltrexone
or alcohol is taken


Also, my thought about hangovers. MAYBE...alcoholics are just depleted in the endorphins. Natural pain killers. Their body is depleted by morning, maybe a few hanging around...so they get the hangover. But, upon hearing how horrible nal hangovers are...maybe they have no access to endorphins until the 50mg is out of their system.

I also think there is a possibility that alcoholics are either endorphin depleted or they have a (genetic) deficient....hence why the drink. If that is the case...I believe ldn would be beneficial. They COULD be craving endorphin and getting them commercially (via drink) ldn would give it to them naturally via blocking & then re uptake.

Is that killer or what? :P

I could be talking out of my ass but it makes sense to me

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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 6:53 pm 
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Location: Orange County, CA, USA
Brilliant! :) If I could,I would love to retitle this post to attract discussion from from someone who actually knows something. ARE there any experts here or just us inmates?

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Now 2 beer max per day.
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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 7:09 pm 
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steven wrote:
Brilliant! :) If I could,I would love to retitle this post to attract discussion from from someone who actually knows something. ARE there any experts here or just us inmates?



inmates...lol.

Okay, I got another thought. Say for instance one was wanting to go out with their buds. Okay about the 5 or 6 drink mark, ya start thinking, okay, this is all I want to pay for tomorrow.(via hangover) This is my buzz & I am cool with it and really don't want to go any further. So...you pop your dosage, (kinda calculating the hours, the half life etc. so in the morning the endorphin rush hits you) hang out, enjoy the buzz, dance a few, sip on one or two (if possible) if not some water...

Next morning, endorphin rush.... no hangover, have some good sex, an extremely healthy breakfast & even get in a bit of exercise.

That's the way to do it. Only an inmate could think up this **** :P

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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 9:32 pm 
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Posts: 56
interesting thoughts, all. I really opened a can of worms with my back of the cocktail napkin calculation regarding low dosage vs hi dosage.

During my first few days on the pill, I had a similar theory to what Steven had. because I really wanted to minimize the amount of chemicals I was putting in my body. Funny! To think of an alcoholic wanting to minimize the use of chemicals. Anyway, the point of my calculations and so forth was not to confuse Stephen or create a debate, but just rather to make sure that he doesn't accidentally underdose himself while trying to be creative with the process.

Like I said, I had the same idea, and someone commented on my thread, and said basically the same thing... Like, just follow the process, don't risk messing it up.

as a brand new convert to use of the pill, I am still on cloud nine about it to some extent. I feel the first control I have had over my drinking behavior years, really. I feel like I am relating to alcohol like a normal person! I love the confidence that comes with knowing that I can actually have a drink or a couple of drinks with friends without being the fool that is literally or figuratively dancing on tables 3 hours later.

it sounds like Stephen is having some great initial success too! like someone else said on the thread, if he can tolerate the full dose, then he should go ahead and take it unless there's some really reliable science that proves otherwise. Just to be on the safe side.

I'm probably being over cautious? Because I'm so new to this process I don't even want to psychologically feel that there is any risk to my opiates being or becoming unblocked when I drink .

anyway! Great job so far Steven! Keep us posted. Sorry for any spelling errors or grammatical mistakes, I am using voice to text


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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 9:55 pm 
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Location: Orange County, CA, USA
Hi Brit. I fully intend to follow your good advice and not tempt fate. I'm mostly intrigued by the discussion and also thinking about Mason's NAL intolerance problem.

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Start TSM 4/20/15
Pre TSM 30-40 AF/0
Now 2 beer max per day.
On LDN (4mg Nal)


Last edited by steven on Tue Apr 28, 2015 10:00 pm, edited 2 times in total.

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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 9:56 pm 
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Posts: 127
Location: Portland, Ore.
I just keep going back to the Pavlov example. Nal is like putting bell-canceling headphones on one of his salivating dogs (a funny thing to imagine). The bell can be ringing for hours and the dog isn't going to be triggered cause he can't hear it. If the bell-canceling-ness wears down (like the batteries run down) then the dog is going to start to hear it and he's going to start to drool. What does it matter how long else the bell has been ringing? If the brain gets the bell signal, it's going to think food's on the way. The drool isn't an instant reaction to food or chewing or flavor; it's a preparatory action for the food, a little mouth yippee that food's coming.

I think the rush of booze is the same as the salivation. It's not that you yet need/earn the saliva but that you're so ready for the whole experience, you're already there.

Your system knows that once the bourbon passes the tongue, fun times are ahead and it'll rev the opiate motors (just like the dog will salivate). The whole point of extinction is to keep bourbon on your tongue and booze in your blood and let your inner dog stop salivating cause the food never comes.

Wow, the only thing I mix better than metaphors are my drinks. :lol:

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Heavy drinker for 15 years.
Started TSM 4/23/15
PreTSM: 68 (0 AF)
Week 1: 40 (0 AF)
2: 51 (1 AF)
4: 39 (1 AF)
6: 24 (3 AF)
8: 9 (5 AF)
10: 11 (4 AF)
12: 24 (3 AF)
14: 19 (4 AF)
15: 26 (3 AF)


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 Post subject: Re: First week, self administered. Some questions.
PostPosted: Tue Apr 28, 2015 10:07 pm 
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Location: Orange County, CA, USA
That's pretty good! If the rush is the bell and it only rings once....

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Pre TSM 30-40 AF/0
Now 2 beer max per day.
On LDN (4mg Nal)


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