Yeah. What he said. We need an expert on board.
Steve

I don't have references to hand, but I would have thought it'd be reasonable to assume that any un-metabolized AL in your system is active on the brain. BAC (Blood Alcohol Concentration) is a pretty universally accepted measure of drunkenness, regardless of time since last drink, or any other variables.

the general rule of thumb for metabolism of AL is about 1/2 a US unit/1 UK unit per hour, although this does depend somewhat on age, sex & weight.

I'm a girl. And I just now found this in the book.



Here is the thing that I have noticed. The time off of nal, in the hours when the reuptake is the biggest (depending on dosage) you can reinforce the behaviors you want. Because the body is flooded with endorphins. In other words, do all of the things that you don't want to do while you are on nal & the receptors are blocked. When off of nal & the endorphins are crazy, do those things that you think you should be doing & that are healthy.

Even though I cannot at this point and time, take a very big dose, when the natural endorphins hit, (and I can feel them) I will only engage in behaviors that I feel are healthy. I was reading in the book where it said the first taste of chocolate during the reuptake was crazy. But, it's like...why would you do that. Why wouldn't you go for broccoli instead? Geesh, now we have a chocolate addiction in the works.

Thanks. My understanding is the body is able to metabolize one drink per hour. Like one beer per hour, or one whiskey. I don't know where I got that from. So, are you saying that we process 1/2 per hour of what we drink? If so, that is good to know. Okay, another thing, I understand that it could be a measure of drunkenness, but does that mean the opiate crap is going on in the brain. Because many folks here say they get the buzz (and even drunk) even while on nal....and we know there is not opiate crap going on because that part is shut down from the nal.

Can drunkedness actually be a part of the equation? Proof that the opiate/endorphin system is still in play?

You see what I am saying?

Sorry Mason. Again, what SHE said. Also on rethinking my experience, sex 3hr after NAL was impossibly frustrating to just impossible. Sex 15hr after NAL was QUITE rewarding. This sort of belies to me the 24hr coverage theory.

Also I think we are knocking around the question of basically what is the important period to be NAL protected. Is it whenever there is unmetabolized alc in the system or is it just the initial rush/gratification stage.

Yes! is it the initial rush/gratification or the unmetabolized alc. You nailed it there. Okay my thought here is the mantra of one hour, one pill. If we are looking at the unmetabolized alc...then hell. one could take the pill during the drinking process & still be protected. Okay, so you have 2 beers in your system, & take a pill then and continue for 6 more....and the 6 more is protected. Did I say that right?

I actually thought that the endorphin/opiate system ran on the initial rush/gratification. Not the un- metabolized alc. I'd really like to know where I could find this info. My searching is not leading me to a whole hell a lot of places.

The rather new use of ULTRA LOW dose NAL in combination with opiate painkillers to block addiction to the opiate would seem to indicate the initial rush period is what is important.

Sorry if I'm not getting it, but how does your reward center know it's the first drink or the fortieth? As soon as it gets AL in the blood, it's happy hour for it even if that alcohol was from a beer you chugged two hours ago or a shot of vodka you took five minutes ago.

I thought so too. But that is the initial rush period of every drink. After that, it goes into metabolic. Is that your understanding? I didn't think it had a lot to do with metabolic. I thought when it enters the metabolic stage the rush period is over. The body is metabolizing it, not the brain. The brain already got it's fix. That's why we need another drink. To get more of that rush for the brain.

Again, I go back to the 50mg dosage. Do the math. It covers a 24 hour period because the 50mg dosage was about abstinence in all of the trials. Nal has a half life of 4 hours....pretty obvious, huh?